Molecular design of specific metal-binding peptide sequences from protein fragments: Theory and experiment

Abstrakt

A novel strategy is presented for designing peptides with specific metal-ion chelation sites, based on linking computationally predicted ion-specific combinations of amino acid side chains coordinated at the vertices of the desired coordination polyhedron into a single polypeptide chain.

Klíčová slova

• ab initio calculations
• massspectrometry
• metal-ion chelation
• molecular design
• peptides