The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice

Abstract

Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes does not significantly influence the ability of the most effective individual oxime (HI-6) to reactivate sarin-inhibited rat acetylcholinesterase in rats and to reduce acute toxicity of sarin in mice.

Keywords

• sarin
• acetylcholinesterase
• HI-6
• trimedoxime
• K203
• rats
• mice