Publication at Faculty of Medicine in Hradec Králové |
2009
Abstract
A catecholamine (isoprenaline - ISO) model of myocardial injury, which has appeared to be very similar to acute myocardial infarction (AMI) in human was used to study the etiopathogenetic mechanisms of AMI. ISO caused marked myocardial injury that was associated with myocardial calcium overload.
Close correlation between myocardial impairment and the levels of myocardial calcium was observed. Direct reactive oxygen species (ROS) involvement was documented only by non-significant increase in malonyldialdehyde 24 hours after ISO injury.