Publication at Faculty of Medicine in Hradec Králové |
2009
Abstract
In this report, we describe the homing of hematopoietic stem cells (HSCs) to non-hematopoietic tissues in lethally irradiated (9 Gy) hybrid mice transplanted intravenously with lin-/CD117+ bone marrow cells from ROSA26 mice. Hematopoietic stem cell transplantation led not only to recovery of hematopoietic and lymphoid tissues but also facilitated recovery of the small intestinal mucosa, which was significantly damaged by ionizing radiation.