Abstract
Conclusions: 6-TG is effective in the treatment of experimental mice colitis, it's liver toxicity assessment requires further studies (e.g. high-dose, long-term). 6-TG nucleotides accumulation is highly variable. Approximately one fourth of patients may demonstrate time to steady state longer than 75 days.
CS are very efficacious in reaching remission and management of relapse in paediatric Crohn disease. Cumulative dose of CS during the first year after diagnosis didn't reached values, that are (according to known data) linked to growth failure.
AZA treatment contributes to lower exposition to CS, decreases frequence of CS dependence, and helps to maintain long-term remission.