K-ras Mutation as a Prognostic Factor in Colorectal Carcinoma

Abstract

The main objective of the project is to prove K-ras mutation in tumors of the colorectum; to defect tumor cells with K-ras mutation in peripheral blood; to defect K-ras mutation in liver metastases; and to verify the hypothesis claiming that tumors with K-ras mutation have a worse prognosis and often lead to disemination, mainly to the liver. The project has been running since June 2004 to December 2006, 76 patients meeting defined parameters have been included in the file to date.

K-ras mutation has been detected in the tumor tissue of 25 patients (33%). K-ras mutation hasn´t been detected in the blood

Keywords

• colorectal carcinoma
• K-ras mutation
• PCR analysis
• venous drainage of the tumor
• detection of tumor cells in peripheral blood