Anti-inflammatory effect of flavonoids from Comfort-G and the changes in arachidonic acid metabolism

Abstract

Flavonoids from preparation Comfort-G have, beside of antioxidant effects, the anti-inflammatory effect, too. Comfort-G inhibits both COX-1 (cyclooxygenase-1)/COX-2 and 5-LO (5-lipoxygenase) enzymatic activity thereby decreasing the transformation of arachidonic acid (AA) to prostaglandins, thromboxanes, and leukotrienes.