Gastrointestinal Permeability - a Parameter of Possible Prognostic Importance in Metastatic Coloretal Carcinoma

Abstract

We have retrospectively analyzed pretreatment parameters of gastrointestinal permeability and urinary neopterin in 21 consecutive patients with metastatic colorectal carcinoma treated with the ombination of cetuximab, irinotecan, leucovorin and 5-fluorouracil. Present data demonstrate that gastrointestinal permeability is associated with systmic immune activation and may be of prognostic significance in patients with metastatic colorectal carcinoma.