Experimental use of selected cholesterol-lowering drugs as potential candidates in modification of the pathophysiology of Alzheimer´s dementia

Abstract

Our studies bring additional evidence of the role of statins in the brain cholesterol synthesis and are the first to show an influence of statins and alendronate on AChE activity in the rat brain. However, our data question the relationship between amyloid beta, acetylcholinesterase activity and cholesterol synthesis.

For comparison of the effects of statins in selected parts of the brain, the deuterium technique was utilised for the first time.