Abstract
The aim of the work was to monitor metabolic changes occurring in the extracellular space of the skeletal muscle during cardiac operation using interstitial microdialysis. With the help of microdialysis, two standard methods of myocardium revascularisation operations for ischemic heart disease were compared.
Operations performed in cardiopulmonary bypass and operations without cardiopulmonary bypass. The aim of the second part of the work was to evaluate tissue (extracellular) concentrations prophylactic administered antibiotic during cardiac operation in cardiopulmonary bypass.
To assess the level of adequacy of the standard applied dose scheme of selected antibiotic given in prophylactic form during cardiac operations in cardiopulmonary bypass and to assess the effect of cardiopulmonary bypass on the distribution of antibiotic in peripheral tissue.