Study of stereoselectivity of reduction of 18-oxo des-E triterpenoids by sodium borohydride in the presence of cerium chloride

Abstract

Stereoselectivity of the reduction of the 18-oxo group in cytotoxically active des-E lupane derivatives was described. It was found that the stereoselectivity of the reduction of the 18-keto group both depended on the type and length of the substituent chain at the position 17.

Keywords

• stereoselectivity
• reduction
• triterpenoid
• borohydride