Within-session reproducibility of motion-onset VEPs: Effect of adaptation/habituation or fatigue on N2 peak amplitude and latency

Abstract

We explored the effect of repeated visual stimulation on motion-onset visual evoked potentials (M-VEPs) during 25 min recording sessions in 10 subjects. The aim of the experiment was to determine influence of global motion adaptation (without motion-aftereffect) on intra-individual variability of M-VEPs and to suggest an optimal recording design for clinical examination.

In addition to well described middletime sensory adaptation, we also observed a long-time effect on motion specific N2 peak (155 ms). The N2 peak exhibited a strong relationship between its latency and inter-peak amplitude to the duration of recording in occipito-parietal derivations.

In addition to the middle-term adaptation, N2 peak latency was prolonged by 10 ms and amplitude was attenuated by 30% with respect to the start of the experiment. An exponential model was employed to describe the dependency.

The model can be used to reduce intra-individual variability during examination.