The use of biochemical markers in assessment of acute and chronic cardiotoxicity of anthracyclines in hematooncology patients
2007
Abstract
Monitoring of acute and chronic cardiotoxicity of anthracyclines in acute leukemia patients with biochemical markers (NT-proBNP, cTnT,CK-MB mass). Our study shows that anthracycline treatment is associated with acute and chronic neurohumoral activation of cardiac dysfunction that is manifested by a significant increase in NT-proBNP.
According to our results, anthracycline treatment, even in higher cumulative doses, does not lead to detectable acute injury to cardiomyocyte structure.