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Measurement of thyroid hormones in serum by microarrays using the Randox Evidence Investigator System - short comminication

Publication at Faculty of Medicine in Hradec Králové |
2007

Abstract

Presented is the pilot study using Randox Evidence Investigator biochip array technology in measurement of thyroid hormones in serum compared to electrochemiluminiscent immunoassay by Modular E-170 (Roche). The Bland and Altman plots comparing two measurements techniques shows statistically significant differences in results.

We determined bias (95% confidence interval): -1,3 to 2,7 mU/l for TSH: -1,7 to 3,0 mU/l for TSH (Thyroid free panel): -53,9 to 54,0 nmol/l (total T4), -1,11 to 0,66 nmol/l (total T3), -4,7 to 3,0 pmol/l (free T4 and -1,4 -4,2 pmol/l (free T3). The main reason for result differences appears to be in insufficient harmonisation of biochip and routine method calibrations.