Publication at Faculty of Medicine in Hradec Králové |
2007
Abstract
Papillary thyroid carcinoma is the most common tumor of the thyroid gland. The activation of several genes is important for its development, mainly the formation of rearrangements of genes encoding tyrosine kinases (RET proto-oncogene and NTRK1 proto-oncogene) with other genes, somatic mutation in BRAF gene and the increased amplification of met proto-oncogene are found.
Minor genetic changes occur in other genes - PTEN, RAS, TP53 and AKAP9. Identification of these specific genetic alterations can contribute to precesing the diagnosis from fine-needle aspiration biopsy before surgery, explanation of the origin of carcinomas and establishment of prognosis of the disease.