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In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

Publication at Faculty of Medicine in Hradec Králové |
2007

Abstract

In this study we examined the release kinetics of cTnT and cTnI using an in vitro model of NVCM and compared it with data from a model of anthracycline-induced cardiomyopathy in vivo. With 3 uM daunorubicin, the relative increase of AUC of cTnT and cTnI was 2.4 and 5.3-fold higher than the increase of LDH activity, respectively.