Surface activation leukocyte markers and humoral factors in cord blood of newborns at risk of early infection
2006
Abstract
Due to immaturity of both specific and non-specific immune mechanism, neonates are at risk of serious infections. The risk group is defined widely, clinical signs are non-specific and common laboratory markers are not as useful as in later age due to delayed reaction.
The search for early, sensitive and specific markers led us to try to distinguish between the patients at risk and the patients without risk factors by the assessment of a defined set of surface leukocyte markers and humoral factors in the cord blood. Several differences were noted - the children at risk of infection had higher proportion of CD19+/23+,CD16+/64+,CD45RO cells and higher level of IL-6.