Charles Explorer logo
🇨🇿

Dissociation of nystatin and amphotericin analogues: characterisation of minor anti-fungal macrolides

Publikace na Přírodovědecká fakulta |
2010

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

Tandem mass spectrometry combined with Fourier transform ion cyclotron resonance (FT-ICR) has been the basis for rationalizing the fragmentation mechanisms of anti-fungal macrolides nystatin A(1) amphotericin B and pimaricin. The positive ion mass spectra were not informative, however, the dissociation of deprotonated molecules Led to structurally significant ring-opened fragments.

Using this approach of tandem FT-ICR mass spectrometry and electrospray ionisation coupled with high-performance Liquid chromatography (HPLC), 11 macrolide natural analogues or degradation products were characterised in the nystatin mixture.