Publication at Faculty of Medicine in Hradec Králové |
2005
Abstract
Normoglycaemia is the most important factor for the prevention, the onser and the development of diabetic nephoropathy. The choice of optimal mode of the therapy is determined based on the stage of nephropathy.
Special attention is required for the management of microalbuminuria because the endothelial damage might be revesible. Insulin therapy of glinides and thiazolodinediones instead of the treatment with sulphonylurea and metformin are suggested to compensate hyperglycaemia and to avoid the risk of hypoglycaemia and lactic acidosis both in renal insufficiency and dialysis.
The short and logn analogues of insulin are suitable for the therapy.
