Genetic dependence of vascular malformations of the nervous system

Abstract

Apart from unequivocally inherited vascular lesions a possible role of acquired postnatal gene mutations are discussed as involved in the pathogenesis of the vascular malformations. Angiogenic factors in CNS resulting from alteration of genome and proteome are reviewed with a special regard to cavernous cerebral malformation (CCM) and arteriovenous malformation (AVM).

Keywords

• vascular malformations of CNS
• cavernous cerebral malformation
• arteriovenous malformation
• genetics of CCM
• genetics of AVM
• angiogenic factors