S,N-Chelated organotin(IV) compounds containing 6-phenylpyridazine-3-thiolate ligand - structural, antibacterial and antifungal study
Abstrakt
A series of tri- and diorganotin(IV) compounds containing potentially chelating S,N-ligand(s) (L(SN), where L(SN) is 6-phenylpyridazine-3-thiolate) were prepared and structurally characterized by multinuclear NMR spectroscopy. X-ray diffraction techniques were used for determination of the structure of compounds containing one [(L(SN))Ph(2)SnCl], two [(n-Bu)(2)Sn(L(SN))(2)] and the combination of two L(SN) and one L(CN) [(L(CN))(n-Bu)Sn(L(SN))(2)] (where L(CN) is {2-[(CH(3))(2)NCH(2)]C(6)H(4)}-) ligands.
The coordination number of the tin atom varies from five to seven and is dependent on the number of chelating ligands present. The formation of the five-membered azastanna heterocycle is favored over the formation of four-membered azastannathia heterocycle in compounds containing both types of ligands.
The di-n-butyl-substituted compounds are the most efficient ones in inhibition of growth of yeasts, molds and G(+) bacteria strains.