Monooxime-monocarbamoyl bispyridinium xylene-linked reactivators of acetylcholinesterase - synthesis, in vitro and toxicity evaluation, and docking studies
2010
Abstract
26 monooxime-monocarbamoyl xylene linked bispyridinium compounds were prepared and tested in vitro along with known reactivators on a model of tabun- and paraoxon-, methylparaoxon- and DFP-inhibited human erythrocyte AChE. Some newly prepared compounds showed promising reactivation of pesticide-inhibited AChE.
The acute toxicity was also determined. Docking studies using tabun-inhibited AChe were performed for 3 compounds.
SAR study confirmed the apparent influence of the xylene-linkage and carbamoyl moiety on the reactivation ability and toxicity of the agents.