Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase
2010
Abstract
Butyrylcholinesterase is considered to be an endogenous stoichiometric bioscavenger of organophosphorus compounds (OPs), but due to limited concentration of BChE in the organism, stoichiometric reduction of OP is not always sufficient. This can be improved by creating a pseudo-catalytic scavenger adding oximes as reactivators of inhibited exogenous BChE.
On order to improve the BChE scavenging function in tabun and paraoxon poisoning, in vitro reactivation of phosphorylated human plasma BChE by bispyridinium oximes was studied, and some SAR were derived.