In vitro oxidative metabolism of xenobiotics in the lancet fluke (Dicrocoelium dendriticum) and the effects of albendazole and albendazole sulphoxide ex vivo

Abstract

The aim of our project was to find out which enzyme of the lancet fluke is responsible for albendazole (ABZ) sulphoxidation, as well as to assay the activities of oxidation enzymes. We also studied whether ex vivo 24-h exposures of flukes to ABZ or its sulphoxide (ABZ.SO) would alter ABZ sulphoxidation rate and the activities of tested enzymes.

Keywords

• oxidative enzymes
• biotransformation
• anthelmintics
• parasitosis