Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

Abstract

The paper deals with gene regulation of CYP3A4 gene in intestinal and hepatic cells via pregnane X (PXR) and Vitamin D (VDR) nuclear receptors.

Keywords

• pharmacokinetics
• metabolism
• cytochrome P450
• CYP3A4
• transcriptional regulation
• nuclear receptors