Synthesis, antimycobacterial, antifungal and photosynthesis-inhibiting activity of chlorinated N-phenylpyrazine-2-carboxamides

Abstrakt

Sixteen newly prepared pyrazinecarboxamides were evaluated for their antimycobacterial, antifungal and photosynthesis-inhibiting activity. 6-Chloro-N-(4-chlorophenyl)pyrazine-2-carboxamide manifested the highest activity against Mycobacterium tuberculosis strain H37Rv (65% inhibition at 6.25 micro-g/mL).

Klíčová slova

• pyrazinecarboxamides
• antimycobacterial activity
• lipophilicity determination