Synthesis and in vitro evaluation of new tacrine derivatives - bis-alkylene linked 7-MEOTA

Abstrakt

Formely, 7-MEOTA was investigated as promising tacrine analogue beneficial for its low toxicicity compared to tacrine. In this study bis-alkylene linked 7-MEOTA derivatives were prepared from 7-MEOTA and corresponding diiodoalkanes.

The novel compounds exhibit anticholinesterase (anti-AChE nad anti-BChE) activity in vitro.

Klíčová slova

• acetylcholinesterase
• butyrylcholinesterase
• Alzheimer&apos
• s disease
• tacrine
• inhibition selectivity