Publication at Central Library of Charles University |
2010
Abstract
The aim of this study was to investigate the influence of amiodarone pretreatment on the main multidrug transporting proteins, Mdr1 and Mrp2, in the liver and kidney. Our results indicate that repeated administration of amiodarone to rats is associated with significant increase in hepatic and renal expression of Mdr1 and Mrp2 transporters.