Synthesis and structure-activity relationships of skin ceramides

Abstrakt

Review of syntheses of sphingosine, 6-hydroxysphingosine, alpha-hydroxy acids and omega-linoleyloxy acids found in skin and their structural requirements for a competent skin barrier.

Klíčová slova

• sphingolipids
• ceramides
• sphingosine
• skin barrier
• stratum corneum
• structure-activity relationships
• synthesis