Distinguishing the cyanobacterial neurotoxin beta-N-methylamino-L-alanine (BMAA) from its structural isomer 2,4-diaminobutyric acid (2,4-DAB)

Abstrakt

The cyanobacterial neurotoxin beta-N-methylamino-L-alanine (BMAA) could be distinquished from 2,4-DAB using reversed-phase HPLC, quadrupole LC-MS/MS analysis or in amino acid analyzer with post-column visualization.

Klíčová slova

• non-protein amino acids
• cyanobacteria
• neurotoxicity
• diaminobutyric acid
• excitotoxicity
• amyotrophic lateral sclerosis
• BMAA
• 2,4-DAB