Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes

Abstract

The study examined stereoselective interaction of R- and S-enantiomers of warfarin with PXR nuclear receptor, which controls the most important cytochrome P450 enzymes.

Keywords

• CYP3A4
• cytochrome P450
• enantiomers
• gene regulation
• PXR
• warfarin