Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells

Abstrakt

Carbonyl reductase 3 (CBR3; SDR21C2), a member of the short-chain dehydrogenase/reductase (SDR) superfamily, has been poorly characterized so far, and the regulation of its expression is a complete mystery. Here, we provide for the first time evidence that human CBR3 expression is regulated via Nrf2, a key regulator in response to oxidative stress.

Klíčová slova

• antioxidant response element
• transcription factor Nrf2
• aldo-keto reductase
• NF-Kappa-B
• gene-expression
• oxidative stress
• chemopreventive agents
• mediated expression
• signaling pathways
• Keap1-Nrf2 pathway