An innovative approach to the analysis of 3-[4-(2-methylpropyl)phenyl]propanoic acid as an impurity of ibuprofen on a carbon-coated zirconia stationary phase

Abstract

A novel reversed-phase HPLC method was developed to simplify the evaluation of pharmacopoeial impurity F of ibuprofen, 3-[4-(2-methylpropyl)phenyl]propanoic acid.

Keywords

• carbon-coated zirconia
• ibuprofen
• impurities
• pharmaceutical analysis
• HPLC