Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: Effects of linking chain length, chirality and polyfluorination

Abstract

Series of N,N-dimethylamino acid esters was synthesized to study their transdermal permeation-enhancing potency, biodegradability and reversibility of action. Effects of chirality, linking chain length and polyfluorination were investigated.

Novel highly active enhancers with advantageous properties were identified.

Keywords

• biodegradability
• permeation enhancers
• reversibility
• structure-activity relationships
• transdermal drug delivery