Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

Abstract

In the current paper, we demonstrate the existence of functional cross-talk between AhR and GR signalling pathways and provide convincing evidence that dexamethasone, a prototype synthetic agonist of GR, controls CYP1A2 expression and CYP1A1/2 activity in primary human hepatocytes.

Keywords

• drug metabolism
• cytochrome P450
• glucocorticoids
• dioxin receptor
• human liver