Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: Effect of drug efflux transporters and lipid solubility

Abstract

In this study we investigate the effect of Bcrp and P-gp on the transplacental pharmacokinetics of their specific and common substrates employing the technique of dually perfused rat placenta.

Keywords

• transplacental pharmacokinetics
• drug efflux transporters
• lipid solubility