Preparation and in vitro evaluation of benzylsulfanyl benzoxazole derivatives as potential antituberculosis agents

Abstrakt

A set of 2-benzylsulfanyl derivatives of benzoxazole was synthesized and evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis, non-tuberculous mycobacteria and multidrug-resistant M. tuberculosis.

Klíčová slova

• benzoxazole
• 2-benzylsulfanyl derivatives
• antimycobakterial activity
• Mycobacterium tuberculosis
• multidrug-resistant M. tuberculosis
• non-tuberculous mycobacteria
• quantitative structure-activity relationship