In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity

Abstract

The results of work demonstrate that although low levels of highly culture-dependent P-gp transporter activity could be measured in cell-lines, these should not be interpreted to mean that P-gp is a significant determinant of inhaled drug disposition in lung.

Keywords

• airways
• drug disposition
• normal human bronchial epithelium
• P-gp
• transport