Development and validation of an LC-ESI-MS ion-trap method for analysis of impurities in transkarbam 12, a novel transdermal accelerant

Abstrakt

In this study a new, sensitive LC/MS method was developed for evaluation of the purity of Transkarbam 12 (T12), validated for analysis of three impurities and finally applied to analysis of T12 bulk substance.

Klíčová slova

• column liquid chromatography-mass spectrometry
• transkarbam 12
• transdermal drug delivery
• penetration enhancers
• impurity analysis