Comparison of 111In-DOTA-NOC and 111In-DOTA-TATE distribution in the target and dose-limiting tissues: conflicting results in vitro and in vivo

Abstract

Results of biodistribution in rats and internalization in OK cells and AR42J cells were compared for two receptor-specific púeptides: 111In-DOTA-NOC and 111In-DOTA-TATE

Keywords

• somatostatin analogues
• 111In-DOTA-1-Nal3-octreotide
• 111In-DOTA-Tyr3-octreotate
• tumor targeting
• renal handling
• biodistribution
• AR42J cells
• OK cells