In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients

Abstract

For a two-dimensional model membrane consisting of a biphasic stratum corneum and a homogeneous epidermal/dermal compartment methods are presented to determine all relevant input parameters

Keywords

• partition coefficient
• diffusion coefficient
• modeling skin penetration
• tape-stripping
• flufenamic acid
• caffeine