Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

Abstract

Six monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker were synthesized; their potency to reactivate AChE inhibited by the nerve agent tabun and insecticide paraoxon was tested in vitro; one reactivator seems to be promising againts tabun-inhibited AChE and two reactivators against paraoxon-inhibited AChE

Keywords

• acetylcholinesterase
• reactivation
• nerve agent
• tabun
• pesticide
• paraoxon
• reactivator
• oxime
• inhibition