New hydrophobicity constants of substituents in pyrazine rings derived from RP-HPLC study

Abstract

New hydrophobicity constants of substituents on pyrazine based on RP-HPLC results were derived; the constants are markedly different from tabulated constants for benzene rings, and can be widely used in estimating physicochemical properties of new biologically active pyrazines

Keywords

• lipophilicity
• pyrazinecarbonitrile
• acetylpyrazine
• homolytic alkylation
• homolytic acetylation
• hydrophobicity
• chromatography
• pyrazines