Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: Cellular iron chelation mediating cytotoxic activity

Abstract

Thiosemicarbazones and N,N-dimethylthiosemicarbazones derived from acetylpyrazines were prepared; the compounds were tested for antifungal effects on eight strains of fungi and also for antitumor activity against SK-N-MC neuroepithelioma cells; the mechanism of action of the compounds was due, at least in part, to its ability to act as a tridentate ligand that binds metal ions

Keywords

• acetylpyrazines
• thiosemicarbazones
• antifungal activity
• antitumor activity
• iron chelatation