Antimicrobial dosing in critically ill patients requiring renal replacement therapy -maximize efficacy and minimize toxicity!

Abstract

The article summarizes difficulties of adequate antibiotic dosing arising in critical illness and renal replacement therapy requirement. The future of the optimal antibiotic dosing consists in general use of therapeutic drug monitoring and accurate pharmacodynamics targeting.

The paper also comments the review article regarding vancomycin and gentamicin dosing.

Keywords

• pharmacokinetics
• antibiotics
• critical illness
• renal replacement therapy