Interferon gamma receptor expression on granulocytes of cardiac surgical patients is modulated differently by the type of cardiopulmonary bypass used
Abstrakt
Aims: To follow the IFN gamma receptor expression on monocytes and granulocytes of cardiac surgical patients with respect to the type of cardiopulmonary bypass (CPB). Methods: Expression of IFN gamma receptor on monocytes and granulocytes of 26 cardiac surgical patients operated with the use of either "standard" or "miniaturised" CPB was determined by flow cytometry.
Results: The significant increase in IFN gamma receptor expression on monocytes on the 1st and on the 3rd postoperative days was revealed in both groups of patients (p<0.001) irrespective of the type of CPB used, being non-significantly different between groups. In contrast, the expression of IFN. on granulocytes displayed significant differences in terms of the CPB used.
Whereas, in "standard" CPB patients, granulocyte INF gamma receptor expression reached its maximum immediately after surgery (p<0.01), in "miniivasive" CPB patients, the peak in INF gamma receptor expression was postponed to the 1st postoperative day (p<0.05). Statistically significantly higher IFN gamma receptor expression on granulocytes was found in "standard" CPB patients (p<0.05).
Conclusion: Compared to "miniaturised" CPB patients, the significantly higher IFN gamma receptor expression on granulocytes was found in "standard" CPB patients (p<0.05) on the 1st postoperative day.