Publication at Faculty of Medicine in Hradec Králové |
2012
Abstract
Autophagy is an itegral part of cell strategy to overcome adverse living conditions. Moreover, autophagy participates in the protection of cytoplasma against invasion of the intracellular pathogenic bacteria.
Abnormalities in the autophagy are participating on the inability of Crohn's disease patients to mantain gut microbiome homeostasis ultimating in the development of immunopathological reaction in these patients. Autophagy can enhance the survival of autoreactive T cells in multiple sclerosis patients thus contributing to the disease induction and progression.