Authors describe a case of a 57-year-old woman-patient suffering from metastatic colorectal carcinoma who was treated through palliative bio-chemotherapy in the schedule: cetuximab+FOLFIRI. Progression of the dermal disease and papulopustulous progress of the grade III exanthema were detected in a six-week-long period from the therapy initiation.
Timely initiation of local treatment on the basis of cream with 0,1% vitamin K1 application in combination with systematic antibiotic treatment and antihistamines application enabled the patient to continue with biological treatment.