DNA topoisomerase II beta: A player in regulation of gene expression and cell differentiation

Abstract

DNA topoisomerases II regulate conformational changes in DNA topology. They act on double-stranded DNA, catalyzing its relaxation, decatenation and unknotting.

This review summarizes current knowledge on its beta isoform.

Keywords

• Topoisomerase II beta
• Topoisomerase II inhibitors
• Gene expression
• Cell cycle