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Acute initial haemodynamic changes in a rat isoprenaline model of cardiotoxicity

Publication at Faculty of Pharmacy in Hradec Králové |
2012

Abstract

In this study, acute heamodynamic changes after s.c. administration of isoprenaline were followed. Shortly, ISO caused rapid decreases in afterload, preload, diastolic relaxation and filling while a short-term increase in left ventricle contractility was observed.

Similar experiments were performed with salbutamol and difference were discussed.